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- Title
The effect of exercise on osteoprotegerin and TNF-related apoptosis-inducing ligand in obese patients.
- Authors
Davenport, Colin; Kenny, Helena; Ashley, David T; O'Sullivan, Eoin P; Smith, Diarmuid; O'Gorman, Donal J
- Abstract
Biomarkers of cardiovascular (CV) risk are tests that predict a patient's risk of future CV events. Recently, two proteins involved in vascular calcification; serum levels of osteoprotegerin (OPG) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) have emerged as potentially useful biomarkers. OPG levels are positively correlated with CV risk, whereas TRAIL levels show a negative correlation. Exercise training is known to reduce risk factors for CV disease by improving metabolism, vascular biology and blood flow. This study examined the effects of a 6-month exercise training programme on levels of OPG and TRAIL. Pulse wave velocity (PWV) and high-sensitivity C-reactive protein (hsCRP) were measured for comparative purposes.
- Publication
European journal of clinical investigation, 2012, Vol 42, Issue 11, p1173
- ISSN
1365-2362
- Publication type
Journal Article
- DOI
10.1111/j.1365-2362.2012.02703.x