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- Title
Angiotensin blockade in diabetic patients decreases insulin resistance-associated low-grade inflammation.
- Authors
Pavlatou, Maria G; Mastorakos, George; Margeli, Alexandra; Kouskouni, Evangelia; Tentolouris, Nicholas; Katsilambros, Nikos; Chrousos, George P; Papassotiriou, Ioannis
- Abstract
Insulin-resistant states, such as metabolic syndrome and diabetes mellitus type 2 (DM2), have been associated with chronic low-grade systemic inflammation. Elevated levels of interleukin-6 (IL-6), monocyte chemoattractant protein (MCP-1) and C-reactive protein (hs-CRP), are found in patients with type 2 diabetes with and without complications. Angiotensin II (Ang II), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of candesartan, an angiotensin receptror blocker, in the chronic low-grade inflammation observed in DM 2.
- Publication
European journal of clinical investigation, 2011, Vol 41, Issue 6, p652
- ISSN
1365-2362
- Publication type
Journal Article
- DOI
10.1111/j.1365-2362.2010.02453.x