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- Title
Calorie restriction: what recent results suggest for the future of ageing research.
- Authors
Smith, Daniel L, Jr; Nagy, Tim R; Allison, David B
- Abstract
Calorie Restriction (CR) research has expanded rapidly over the past few decades and CR remains the most highly reproducible, environmental intervention to improve health and extend lifespan in animal studies. Although many model organisms have consistently demonstrated positive responses to CR, it remains to be shown whether CR will extend lifespan in humans. Additionally, the current environment of excess caloric consumption and high incidence of overweight/obesity illustrate the improbable nature of the long-term adoption of a CR lifestyle by a significant proportion of the human population. Thus, the search for substances that can reproduce the beneficial physiologic responses of CR without a requisite calorie intake reduction, termed CR mimetics (CRMs), has gained momentum.
- Publication
European journal of clinical investigation, 2010, Vol 40, Issue 5, p440
- ISSN
1365-2362
- Publication type
Journal Article
- DOI
10.1111/j.1365-2362.2010.02276.x