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- Title
Serum regulates cortisol bioactivity by corticosteroid-binding globulin-dependent and independent mechanisms, as revealed by combined bioassay and physicochemical assay approaches.
- Authors
Perogamvros, I; Kayahara, M; Trainer, P J; Ray, D W
- Abstract
Corticosteroid-binding globulin (CBG) is the principal carrier of natural glucocorticoids in the circulation, and we hypothesized that it modulates glucocorticoid bioactivity (GBA). Alterations in CBG, the presence of noncortisol, naturally occurring glucocorticoids and the use of potent, synthetic glucocorticoids, all make it difficult to assess adrenal activity in-vivo; these problems can be addressed by a glucocorticoid bioassay.
- Publication
Clinical endocrinology, 2011, Vol 75, Issue 1, p31
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2011.04003.x