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- Title
The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians.
- Authors
Vaidya, Anand; Sun, Bei; Forman, John P; Hopkins, Paul N; Brown, Nancy J; Kolatkar, Nikheel S; Williams, Gordon H; Williams, Jonathan S
- Abstract
25-Hydroxyvitamin D (25(OH)D) deficiency and excess activity of the renin-angiotensin system (RAS) are both associated with cardiovascular disease. Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. We evaluated (i) whether genetic variation in the VDR at the Fok1 polymorphism was associated with plasma renin activity (PRA) in a population of hypertensives and a separate population of normotensives and (ii) whether the association between Fok1 genotype and PRA was independent of 25(OH)D levels.
- Publication
Clinical endocrinology, 2011, Vol 74, Issue 6, p783
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2011.03991.x