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- Title
Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic dysregulation.
- Authors
Zanni, Markella V; Stanley, Takara L; Makimura, Hideo; Chen, Cindy Y; Grinspoon, Steven K
- Abstract
Endothelial adhesion molecules like E-selectin play an important role in leukocyte recruitment and development of atherosclerotic plaque. E-selectin is increased in obesity, yet little is known regarding the specific factors contributing to elevated E-selectin in obesity and whether tumour necrosis factor alpha (TNF-alpha) increases E-selectin in vivo in this population. The objectives of this study were to: (1) determine the body composition, metabolic and inflammatory factors associated with increased E-selectin and (2) determine the role of TNF-alpha in the physiological regulation of E-selectin by antagonism of TNF-alpha with etanercept among obese subjects.
- Publication
Clinical endocrinology, 2010, Vol 73, Issue 1, p48
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2009.03741.x