We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tissue mRNA expression of the glucocorticoid receptor and its splice variants in fatal critical illness.
- Authors
Peeters, R P; Hagendorf, A; Vanhorebeek, I; Visser, T J; Klootwijk, W; Mesotten, D; Wouters, P J; Koper, J W; de Jong, F H; Feelders, R A; Lamberts, S W J; Van den Berghe, G
- Abstract
Critical illness results in activation of the hypothalamic-pituitary-adrenal (HPA) axis, which might be accompanied by a peripheral adaptation in glucocorticoid sensitivity. Tissue sensitivity is determined by the active glucocorticoid receptor GRalpha, of which two splice variants involving the hormone-binding domain exist, GRbeta and GR-P.
- Publication
Clinical endocrinology, 2009, Vol 71, Issue 1, p145
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2008.03443.x