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- Title
Clomiphene citrate, metformin or both as first-step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head-to-head randomized controlled studies and meta-analysis.
- Authors
Palomba, Stefano; Pasquali, Renato; Orio, Francesco, Jr; Nestler, John E
- Abstract
To date, no systematic review or meta-analysis has been published of direct head-to-head studies comparing clomiphene citrate (CC) vs. metformin, or the combination of both drugs as first-line therapy in anovulatory polycystic ovary syndrome (PCOS) patients seeking pregnancy. The aim of the current paper was to define, if possible, the best evidence-based recommendations regarding the use of CC and/or metformin as the initial treatment of PCOS women with anovulatory infertility.
- Publication
Clinical endocrinology, 2009, Vol 70, Issue 2, p311
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2008.03369.x