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- Title
Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism.
- Authors
Siegmund, W; Spieker, K; Weike, A I; Giessmann, T; Modess, C; Dabers, T; Kirsch, G; Sänger, E; Engel, G; Hamm, A O; Nauck, M; Meng, W
- Abstract
There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well-being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of a physiological combination of thyroid hormones (absorbed molar ratio 14 : 1) over T4 alone with regard to mood states and cognitive functioning.
- Publication
Clinical endocrinology, 2004, Vol 60, Issue 6, p750
- ISSN
0300-0664
- Publication type
Journal Article
- DOI
10.1111/j.1365-2265.2004.02050.x