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- Title
Antibody fragments as tools in crystallography.
- Authors
Griffin, L; Lawson, A
- Abstract
While antibody-based therapeutics have become firmly established as front-line drugs, the use of antibodies as research tools in small molecule drug discovery is still in its infancy. In this review we focus on the use of antibody fragments as crystallization chaperones to aid the structural determination of otherwise 'uncrystallizable' or 'undruggable' target proteins. We also highlight a potential application for this technology, in which antibody-mediated structures may be used to inform the design of new chemical entities.
- Publication
Clinical and experimental immunology, 2011, Vol 165, Issue 3, p285
- ISSN
1365-2249
- Publication type
Journal Article
- DOI
10.1111/j.1365-2249.2011.04427.x