We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group.
- Authors
Matthews, J B; Staeva, T P; Bernstein, P L; Peakman, M; von Herrath, M; ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group
- Abstract
Like many other complex human disorders of unknown aetiology, autoimmune-mediated type 1 diabetes may ultimately be controlled via a therapeutic approach that combines multiple agents, each with differing modes of action. The numerous advantages of such a strategy include the ability to minimize toxicities and realize synergies to enhance and prolong efficacy. The recognition that combinations might offer far-reaching benefits, at a time when few single agents have yet proved themselves in well-powered trials, represents a significant challenge to our ability to conceive and implement rational treatment designs. As a first step in this process, the Immune Tolerance Network, in collaboration with the Juvenile Diabetes Research Foundation, convened a Type 1 Diabetes Combination Therapy Assessment Group, the recommendations of which are discussed in this Perspective paper.
- Publication
Clinical and experimental immunology, 2010, Vol 160, Issue 2, p176
- ISSN
1365-2249
- Publication type
Journal Article
- DOI
10.1111/j.1365-2249.2010.04153.x