We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata.
- Authors
Sotiriadis, D; Patsatsi, A; Lazaridou, E; Kastanis, A; Vakirlis, E; Chrysomallis, F
- Abstract
Highly variable results have been described for the use of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata (AA). We enrolled 41 patients in a prospective open clinical trial. Of these, 17 patients had either AA totalis (AAT) or AA universalis (AAU), and 24 had severe alopecia (> 50% scalp involvement). After sensitization with DPCP 2% in acetone, progressively higher concentrations were applied once a week for a period of 6-12 months. Of the 41 patients, 38 (16 with AAT or AAU and 22 with extensive AA) completed therapy. Significant hair regrowth was observed in 15 of the 38 patients (39.5%) at 6 months: 5 with AAT or AAU (31.25%) and 10 with extensive alopecia (45.4%). The above results were sustained in 66.6% of patients for a 12-month-follow up- period. In our study, topical immunotherapy with DPCP proved to be an effective treatment, with prolonged therapeutic results.
- Publication
Clinical and experimental dermatology, 2007, Vol 32, Issue 1, p48
- ISSN
0307-6938
- Publication type
Journal Article
- DOI
10.1111/j.1365-2230.2006.02256.x