We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness.
- Authors
Gordon, E D; Sidhu, S S; Wang, Z-E; Woodruff, P G; Yuan, S; Solon, M C; Conway, S J; Huang, X; Locksley, R M; Fahy, J V
- Abstract
The pathophysiology of asthma involves allergic inflammation and remodelling in the airway and airway hyperresponsiveness (AHR) to cholinergic stimuli, but many details of the specific underlying cellular and molecular mechanisms remain unknown. Periostin is a matricellular protein with roles in tissue repair following injury in both the skin and heart. It has recently been shown to be up-regulated in the airway epithelium of asthmatics and to increase active TGF-β. Though one might expect periostin to play a deleterious role in asthma pathogenesis, to date its biological role in the airway is unknown.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2012, Vol 42, Issue 1, p144
- ISSN
1365-2222
- Publication type
Journal Article
- DOI
10.1111/j.1365-2222.2011.03840.x