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- Title
An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model.
- Authors
Marinho, F A V; Pacífico, L G G; Miyoshi, A; Azevedo, V; Le Loir, Y; Guimarães, V D; Langella, P; Cassali, G D; Fonseca, C T; Oliveira, S C
- Abstract
Around 300 million people world-wide suffer from asthma, and the prevalence of allergic diseases has increased. Much effort has been used in the study of mechanisms involved in the immune response observed in asthma to intervene for the treatment of this condition. During inflammation in asthma, Th2 cytokines and eosinophils are essential components of the host immune system. Furthermore, for therapeutic interventions against this disease, IL-10 is an important cytokine because it has a central role in the regulation of inflammatory cascades.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2010, Vol 40, Issue 10, p1541
- ISSN
1365-2222
- Publication type
Journal Article
- DOI
10.1111/j.1365-2222.2010.03502.x