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- Title
Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity.
- Authors
Holden, N J; Bedford, P A; McCarthy, N E; Marks, N A; Ind, P W; Jowsey, I R; Basketter, D A; Knight, S C
- Abstract
Chemical haptens induce both contact and allergic respiratory disease with dendritic cells (DCs) controlling and directing immune responses in vivo. Contact and respiratory haptens may promote differential cytokine production yet distinguishing these effects in vitro remains difficult due to human donor variability. Objective We sought to determine the effect of atopic status on the ability of DC to respond to contact and respiratory sensitizer treatment in vitro as DC from atopic donors are believed to promote Th2-type responses.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Vol 38, Issue 7, p1148
- ISSN
1365-2222
- Publication type
Journal Article
- DOI
10.1111/j.1365-2222.2008.02997.x