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- Title
Oral challenges are needed in the diagnosis of beta-lactam hypersensitivity.
- Authors
Bousquet, P J; Pipet, A; Bousquet-Rouanet, L; Demoly, P
- Abstract
beta-lactams continue to remain the most commonly involved drug family in allergic drug reactions. They are often essential and there is a cost-effective and favourable risk-benefit ratio for the exploration of all suspicions of beta-lactam allergy. A firm diagnosis is always based on skin tests and sometimes on provocation tests. Recommendations have been published by allergy societies and distinguished scientists but they are not always concordant and can lead to some confusion for the practicing allergologist. The situation has even worsened since the world wide withdrawal of these penicillin determinants and since the predominance of amoxicillin and cephalosporin prescriptions in most countries. OBJECTIVE - METHOD: In a recent article, it was stated that patients with a penicillin allergy history and negative skin tests to major and minor penicillin determinants are at a low risk of relapse (0-5%) when receiving a beta-lactam. In this paper, our Drug Allergy and Hypersensitivity Database, a cohort database, was used to demonstrate that this statement is false. Standardized European Network for Drug Allergy questionnaires, skin test and challenge procedures were followed.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2008, Vol 38, Issue 1, p185
- ISSN
1365-2222
- Publication type
Journal Article
- DOI
10.1111/j.1365-2222.2007.02867.x