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- Title
Five-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates poly (I:C)-induced airway inflammation in a murine model of asthma.
- Authors
Kim, T-B; Kim, S Y; Moon, K-A; Park, C-S; Jang, M K; Yun, E S; Cho, Y S; Moon, H-B; Lee, K-Y
- Abstract
Asthma can frequently be induced or exacerbated by respiratory viral infections. Oxidative stress might also play an essential role in the pathogenesis of allergic airway diseases, indicating that antioxidant therapy may have a potential effect in controlling allergic airway diseases. Recent studies showed that 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) has the potential ability to modulate NADPH oxidase activity, indicating the antioxidant activity of AICAR. This study investigated the inhibitory effects of AICAR as an anti-inflammatory modulator on allergic airway inflammation in murine animal models.
- Publication
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2007, Vol 37, Issue 11, p1709
- ISSN
0954-7894
- Publication type
Journal Article
- DOI
10.1111/j.1365-2222.2007.02812.x