We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The presence of alpha-thalassaemia trait blunts the response to hydroxycarbamide in patients with sickle cell disease.
- Authors
Vasavda, Nisha; Badiger, Sheela; Rees, David; Height, Sue; Howard, Jo; Thein, Swee Lay
- Abstract
Hydroxycarbamide (HC), although a key drug therapy in sickle cell disease (SCD), does not result in a clinical response in all patients. Increases in fetal haemoglobin (HbF) and mean corpuscular volume of erythrocytes are standard clinical measures of HC efficacy in SCD. Genetic studies have determined that the majority of HbF regulation occurs outside the beta-globin locus. Approximately 30% of SCD patients have co-inherited alpha-thalassaemia resulting in hypochromic and microcytic erythrocytes. We provide data from 30 SCD patients (10 with alpha-thalassaemia) demonstrating that co-existing alpha-thalassaemia significantly affects several standard measures of HC efficacy in SCD.
- Publication
British journal of haematology, 2008, Vol 143, Issue 4, p589
- ISSN
1365-2141
- Publication type
Journal Article
- DOI
10.1111/j.1365-2141.2008.07375.x