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- Title
The aetiology and management of Castleman disease at 50 years: translating pathophysiology to patient care.
- Authors
Casper, Corey
- Abstract
Fifty years ago, Dr Benjamin Castleman first described the unusual lymphoproliferative disorder that now bears his name. Over the subsequent decades, astute clinical and pathologic observations coupled with clever molecular biologic research have increased our understanding of the aetiology of Castleman disease (CD). This article proposes three broad CD variants based on both distinctive histopathology and clinical behaviour. The pivotal roles of infection with human herpesvirus 8 and interleukin-6 production in the development of CD are emphasized. Finally, the natural history of CD and the myriad of therapeutic options are reviewed in the context of a unified model of CD pathophysiology, and continued areas of uncertainty are discussed.
- Publication
British journal of haematology, 2005, Vol 129, Issue 1, p3
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1111/j.1365-2141.2004.05311.x