We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Red cell deformability, splenic function and anaemia in thalassaemia.
- Authors
Dondorp, A M; Chotivanich, K T; Fucharoen, S; Silamut, K; Vreeken, J; Kager, P A; White, N J
- Abstract
Red cell deformability (RCD) was measured in 38 patients with alpha-thalassaemia and 48 patients with beta-thalassaemia, of whom 13 had undergone splenectomy. All splenectomized patients, but none of those with intact spleens, had very rigid erythrocytes with an elongation index <0.45 at a high shear stress of 30 Pa suggesting a splenic recognition threshold for removal of rigid red cells. At this shear stress RCD correlated strongly with the degree of anaemia in both the splenectomized (r = 0.81, P < 0.001) and non-splenectomized beta-thalassaemic patients (all patients r = 0.81, P < 0.001; homozygous beta-thalassaemic patients r = 0.51, P = 0. 01). These data suggest that reduced RCD is a major determinant of anaemia in thalassaemia.
- Publication
British journal of haematology, 1999, Vol 105, Issue 2, p505
- ISSN
0007-1048
- Publication type
Journal Article
- DOI
10.1111/j.1365-2141.1999.01367.x