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- Title
Enrichment of total serum IgG4 in patients with pemphigus.
- Authors
Funakoshi, T; Lunardon, L; Ellebrecht, C T; Nagler, A R; O'Leary, C E; Payne, A S
- Abstract
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially fatal blistering diseases caused by autoantibodies targeting desmoglein (Dsg) adhesion proteins. Previous studies have shown an IgG4 > IgG1 predominance of anti-Dsg antibodies in pemphigus; however, no studies have examined total serum IgG4 levels in pemphigus. IgG4 is induced by chronic antigen stimulation, which could occur with persistent skin blistering and potentially elevate the total serum IgG4 relative to other IgG subclasses in patients with pemphigus.
- Publication
The British journal of dermatology, 2012, Vol 167, Issue 6, p1245
- ISSN
1365-2133
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.2012.11144.x