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- Title
Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy.
- Authors
Ibbotson, S H; Dawe, R S; Dinkova-Kostova, A T; Weidlich, S; Farr, P M; Ferguson, J; Wolf, C R; Smith, G
- Abstract
There is marked interpatient variation in responses to psoralen-ultraviolet A (PUVA) photochemotherapy. Identification of molecular biomarkers of PUVA sensitivity may facilitate treatment predictability.The glutathione S-transferases (GSTs) influence cutaneous defence against UV radiation-induced oxidative stress and are therefore candidate biomarkers of PUVA sensitivity. Several human GSTs, including GSTM1 and GSTT1, are polymorphic, and null polymorphisms have been associated with increased UVB erythemal sensitivity and skin cancer risk. PUVA also increases skin cancer risk.
- Publication
The British journal of dermatology, 2012, Vol 166, Issue 2, p380
- ISSN
1365-2133
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.2011.10661.x