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- Title
Ovariectomy is sufficient to accelerate spontaneous skin ageing and to stimulate ultraviolet irradiation-induced photoageing of murine skin.
- Authors
Tsukahara, K; Nakagawa, H; Moriwaki, S; Kakuo, S; Ohuchi, A; Takema, Y; Imokawa, G
- Abstract
Wrinkling and sagging of the skin during photoageing is physiologically associated with diminished elasticity, which can be attributed to increased fibroblast-derived elastase activity. This degrades the dermal elastic fibres needed to maintain the three-dimensional structure of the skin. We previously reported that ovariectomy accelerates ultraviolet (UV)B-induced wrinkle formation in rat hind limb skin by altering the three-dimensional structure of elastic fibres.
- Publication
The British journal of dermatology, 2004, Vol 151, Issue 5, p984
- ISSN
0007-0963
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.2004.06203.x