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- Title
Involucrin expression in keratinization disorders of the skin--a preliminary study.
- Authors
Kanitakis, J; Zambruno, G; Viac, J; Thivolet, J
- Abstract
We have studied the expression of involucrin in a variety of keratinization disorders, mostly of genetic origin using an avidin-biotin-peroxidase technique. In normal human epidermis 25% of the living epidermis was labelled. The diseases studied fell into two groups. Diseases with greatly increased involucrin staining including collodion baby (38%), Darier's disease (49%), Flegel's disease (56%), erythrokeratoderma variabilis (60%), epidermal naevus with epidermolytic hyperkeratosis (45%) and congenital bullous (58%) and non-bullous (44%) ichythyosiform erythroderma; and diseases with normal or slightly increased staining, including ichthyosis vulgaris (27%), X-linked ichthyosis (25%), confluent and reticulate papillomatosis (27%) and simple epidermal naevus (28%). These results demonstrate that involucrin expression is altered in some keratinization disorders and suggest that in such conditions cellular functions other than keratin metabolism are also affected.
- Publication
The British journal of dermatology, 1987, Vol 117, Issue 4, p479
- ISSN
0007-0963
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.1987.tb04928.x