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- Title
Demonstration of a unique viral structure: the molluscum viral colony sac.
- Authors
Shelley, W B; Burmeister, V
- Abstract
Using scanning electron microscopy to study molluscum contagiosum lesions, it has been possible to demonstrate a unique, well defined sac enclosing the virion colony of each infected keratinocyte. This confirms the presence of a structure demonstrated over 50 years ago by micro-dissection, but ignored since it is not seen on either light or transmission electron microscopy. It is postulated that this sac, of unknown origin, favours replication of the virions by providing a site that is both anatomically and immunologically privileged. Such relatively unimpeded growth of the virions results in an enlarged cell in which the cytoplasm and nucleus are compressed into a thin outer shell. In the aggregate, this produces a tumour of virus-packed cells rather than a tumour composed of virus-induced cell hyperplasia.
- Publication
The British journal of dermatology, 1986, Vol 115, Issue 5, p557
- ISSN
0007-0963
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.1986.tb05765.x