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- Title
A double-blind study of the effects of 13-cis-retinoic acid on acne, sebum excretion rate and microbial population.
- Authors
King, K; Jones, D H; Daltrey, D C; Cunliffe, W J
- Abstract
Forty-eight acne patients were treated orally with 13-cis-retinoic acid in a double-blind dose response study. There was a marked clinical improvement with a concomitant reduction in sebum excretion rate (SER) and production rate of free fatty acids (FFA). Microbial numbers decreased significantly; the decrease in propionibacteria was greater than that of aerobic bacteria. The decline in micro-organisms occurred after the reduction in sebum and FFA production. This suggests that the effect of the drug upon micro-organisms is secondary to the change in sebum excretion but it is nevertheless an important factor in the resolution of the acne.
- Publication
The British journal of dermatology, 1982, Vol 107, Issue 5, p583
- ISSN
0007-0963
- Publication type
Journal Article
- DOI
10.1111/j.1365-2133.1982.tb00410.x