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- Title
Systematic review: molecular chemoprevention of colorectal malignancy by mesalazine.
- Authors
Lyakhovich, A; Gasche, C
- Abstract
Mesalazine (mesalamine) (5-ASA) is considered an anti-inflammatory drug for the treatment of inflammatory bowel disease. It is well tolerated by most patients and induces mucosal healing specifically in ulcerative colitis. Besides its anti-inflammatory properties, 5-ASA has been studied for cancer inhibitory activities as it seems to reduce colorectal cancer incidence in patients using this drug for long periods of time. However, detailed molecular mechanisms of drug action are vague.
- Publication
Alimentary pharmacology & therapeutics, 2010, Vol 31, Issue 2, p202
- ISSN
1365-2036
- Publication type
Journal Article
- DOI
10.1111/j.1365-2036.2009.04195.x