Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation.

Hatsukami, Dorothy K.; Kotlyar, Michael; Hertsgaard, Louise A.; Zhang, Yan; Carmella, Steven G.; Jensen, Joni A.; Allen, Sharon S.; Shields, Peter G.; Murphy, Sharon E.; Stepanov, Irina; Hecht, Stephen S.

Aims To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence. Design Randomized, parallel arm, semi-blinded study. Setting University of Minnesota Tobacco Use Research Center. Interventions Six weeks of: (i) 0.05 mg nicotine yield cigarettes; (ii) 0.3 mg nicotine yield cigarettes; or (iii) 4 mg nicotine lozenge; 6 weeks of follow-up. Measurements Compensatory smoking behavior, biomarkers of exposure, tobacco dependence, tobacco withdrawal and abstinence rate. Findings Unlike the 0.3 mg cigarettes, 0.05 mg cigarettes were not associated with compensatory smoking behaviors. Furthermore, the 0.05 mg cigarettes and nicotine lozenge were associated with reduced carcinogen exposure, nicotine dependence and product withdrawal scores. The 0.05 mg cigarette was associated with greater relief of withdrawal from usual brand cigarettes than the nicotine lozenge. The 0.05 mg cigarette led to a significantly higher rate of cessation than the 0.3 mg cigarette and a similar rate as nicotine lozenge. Conclusion The 0.05 mg nicotine yield cigarettes may be a tobacco product that can facilitate cessation; however, future research is clearly needed to support these preliminary findings.

MINNESOTA; NICOTINE addiction treatment; NICOTINE; REHABILITATION of cigarette smokers; SMOKING prevention; CIGARETTES; TOBACCO; DRUG withdrawal symptoms; UNIVERSITY of Minnesota

Addiction, 2010, Vol 105, Issue 2, p343

0965-2140

Academic Journal

10.1111/j.1360-0443.2009.02780.x