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- Title
Primary dermal melanoma: A case report and molecular characterization.
- Authors
Hida, Yasutoshi; Kubo, Yoshiaki; Miyajima, Osamu; Arase, Seiji
- Abstract
Swetter et al. proposed primary dermal melanoma (PDM) as a distinct entity based on an excellent prognosis. The histopathological features of PDM are extremely similar to those of metastatic melanoma or clear cell sarcoma (CCS). We describe a 38-year-old woman with a subcutaneous tumor in her left thigh. Physical and imaging examinations showed no evidence of metastatic melanoma. The lesion showed obvious strong expression of KIT by immunohistochemistry, but no EWS-ATF1 fusion transcript specific for CCS was detected by reverse transcription polymerase chain reaction. In further analyses of KIT expression in other tumors, three of four primary melanomas (75%) and six of 12 metastatic melanomas (50%) were moderately or strongly positive, however, both the primary and metastatic lesions of CCS tested negative. We believe this to be a case of PDM, and emphasize the distinctiveness of PDM.
- Publication
The Journal of dermatology, 2009, Vol 36, Issue 6, p346
- ISSN
1346-8138
- Publication type
Journal Article
- DOI
10.1111/j.1346-8138.2009.00650.x