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- Title
Adjuvant chemotherapy with cisplatin, ifosfamide, and doxorubicin followed by radiotherapy in localized uterine sarcomas: results of a case-control study with radiotherapy alone.
- Authors
Pautier, P; Rey, A; Haie-Meder, C; Kerbrat, P; Dutel, J L; Gesta, P; Bryard, F; Morice, P; Duvillard, P; Lhommé, C
- Abstract
Uterine sarcoma is a poor prognosis disease, with a high risk of metastatic relapse. We conducted a study of adjuvant chemotherapy with cisplatin, ifosfamide, and doxorubicin followed by radiotherapy (n=18). The results were then compared in a matched case-controlled study to radiotherapy alone (n=16) or no therapy at all (n=2). Chemotherapy consisted in three cycles of adriamyein-platinum-ifosfamide (API) (doxorubicin 60 mg /m2 on day 1; cisplatin 100 mg /m2 on day 2; ifosfamide 5 g /m2 on day 1+mesna 5 g /m2 on day 1+granulocyte colony-stimulating factor; q 3 weeks). Drug doses were reduced (20% for ifosfamide and cisplatin) four times (four patients) due to hematologic toxicity. Compared to a case-control study of adjuvant radiotherapy alone, results were not decreased by the addition of a toxic chemotherapy.
- Publication
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2004, Vol 14, Issue 6, p1112
- ISSN
1048-891X
- Publication type
Journal Article
- DOI
10.1111/j.1048-891X.2004.14609.x