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- Title
The immune system, amyloid-beta peptide, and Alzheimer's disease.
- Authors
Weksler, Marc E; Gouras, Gunnar; Relkin, Norman R; Szabo, Paul
- Abstract
In this review, the case is made that amyloid-beta peptide in the brain of patients with Alzheimer's disease is a primary cause of the disease and that immunotherapy directed against this peptide has the potential to halt and/or reverse disease progression. This supposition is supported by the capacity of anti-beta-amyloid peptide antibodies to prevent or reverse the disease in mouse models of Alzheimer's disease. Furthermore, preliminary results obtained in a small number of patients with Alzheimer's disease are consistent with the observations made in the mouse model of this disease. We review the relationship between the immune system, amyloid-beta peptide, and Alzheimer's disease and the progress made in applying immunotherapy to patients with Alzheimer's disease.
- Publication
Immunological reviews, 2005, Vol 205, p244
- ISSN
0105-2896
- Publication type
Journal Article
- DOI
10.1111/j.0105-2896.2005.00264.x