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- Title
Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration.
- Authors
Budimir, Natalija; de Haan, Aalzen; Meijerhof, Tjarko; Gostick, Emma; Price, David A; Huckriede, Anke; Wilschut, Jan
- Abstract
Development of influenza vaccines capable of inducing broad protection against different virus subtypes is necessary given the ever-changing viral genetic landscape. Previously, we showed that vaccination with whole inactivated virus (WIV) induces heterosubtypic protection against lethal virus infection in mice. Whole inactivated virus-induced cross-protection was found to be mediated primarily by flu-specific CD8+ T cells.
- Publication
Influenza and other respiratory viruses, 2013, Vol 7, Issue 6, p1202
- ISSN
1750-2659
- Publication type
Journal Article
- DOI
10.1111/irv.12142