Title

Phosphatidylinositol 3‐kinase signaling pathway and inflammatory bowel disease: Current status and future prospects.

Authors

Jalil, Abduladheem Turki; Hassan, Neeran Flaeh; Abdulameer, Sada Jasim; Farhan, Zainab Mohammed; Suleiman, Ahmed AbdulJabbar; Al‐Azzawi, Abdul Kareem; Zabibah, Rahman; Fadhil, Ali

Abstract

Inflammatory bowel disease (IBD) is a chronic life‐limiting disease of gastrointestinal tract characterized by widespread enteric inflammation. IBD is a multifactorial disease, and different environmental, microbial, and immune‐related factors give rise to the development of disease. Among several factors, the preponderance of pro‐inflammatory T helper 17 cells over the anti‐inflammatory regulatory T cells augments inflammation in the intestinal mucosa. Prevailing evidence accentuates that PI3K signaling pathway plays a central role in the pathophysiology of the condition by regulating the inflammatory process in the gut mucosa. By recognizing the implications of PI3K in the pathogenesis of IBD, agents that could modulate this pathway have recently been at the focus of research, yielding encouraging results mainly in the experimental IBD models. In this review, we have summarized the recent advances, which may hold the keys to identify novel therapeutic strategies for IBD.

Subjects

INFLAMMATORY bowel diseases; PHOSPHATIDYLINOSITOL 3-kinases; GASTROINTESTINAL diseases; CELLULAR signal transduction; REGULATORY T cells; T helper cells

Publication

Fundamental & Clinical Pharmacology, 2023, Vol 37, Issue 5, p910

ISSN

0767-3981

Publication type

Academic Journal

DOI

10.1111/fcp.12894