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- Title
Unravelling hair follicle-adipocyte communication.
- Authors
Schmidt, Barbara; Horsley, Valerie
- Abstract
Here, we explore the established and potential roles for intradermal adipose tissue in communication with hair follicle biology. The hair follicle delves deep into the rich dermal macroenvironment as it grows to maturity where it is surrounded by large lipid-filled adipocytes. Intradermal adipocytes regenerate with faster kinetics than other adipose tissue depots and in parallel with the hair cycle, suggesting an interplay exists between hair follicle cells and adipocytes. While adipocytes have well-established roles in metabolism and energy storage, until recently, they were overlooked as niche cells that provide important growth signals to neighbouring skin cells. We discuss recent data supporting adipocytes as niche cells for the skin and skin pathologies that may be related to alterations in skin adipose tissue defects.
- Publication
Experimental dermatology, 2012, Vol 21, Issue 11, p827
- ISSN
1600-0625
- Publication type
Journal Article
- DOI
10.1111/exd.12001