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- Title
Deterioration of vitiligo and new onset of halo naevi observed in two patients receiving adalimumab.
- Authors
Maruthappu, Thivi; Leandro, Maria; Morris, Susie D
- Abstract
Two patients with a long-standing history of recalcitrant ankylosing spondylitis were commenced on adalimumab as monotherapy. Case 1 developed marked rapid deterioration in his previously stable vitiligo within 3 months of commencing treatment. This was attributed to anti-tumor necrosis factor (TNF) therapy, and a marked improvement was noted following withdrawal of adalimumab. Case 2 developed multiple new halo naevi over the trunk and limbs. They did not show dysplastic features and have remained unchanged despite continuation of treatment. Possible mechanisms and implications of the paradoxical occurrence of immune-mediated skin lesions seen in patients receiving anti-TNF therapies are discussed.
- Publication
Dermatologic therapy, 2013, Vol 26, Issue 4, p370
- ISSN
1529-8019
- Publication type
Journal Article
- DOI
10.1111/dth.12002