We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
GSK-3β inhibition promotes early engraftment of ex vivo-expanded haematopoietic stem cells.
- Authors
Dolnikov, A; Xu, N; Shen, S; Song, E; Holmes, T; Klamer, G; O'Brien, T A
- Abstract
Umbilical cord blood (UCB) is a source of stem cells used for allogeneic transplantation, in addition to bone marrow and peripheral blood. Limited numbers of stem cells in a single UCB unit is associated with slow haematopoietic recovery and high risk of graft failure, particularly in adult patients. UCB stem cells can be expanded ex vivo; however, rapid differentiation reduces their regenerative potential. We have recently shown that Wnt/β-catenin signalling is down-regulated in ex vivo-expanded stem cells; therefore, we propose that re-activation of Wnt signalling using GSK-3β inhibition may act to improve regenerative potential of these ex vivo-expanded stem cells.
- Publication
Cell proliferation, 2014, Vol 47, Issue 2, p113
- ISSN
1365-2184
- Publication type
Journal Article
- DOI
10.1111/cpr.12092