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- Title
Skeletal muscle analyses: agreement between non-contrast and contrast CT scan measurements of skeletal muscle area and mean muscle attenuation.
- Authors
van der Werf, Anne; Dekker, Ingeborg M; Meijerink, Martijn R; Wierdsma, Nicolette J; de van der Schueren, Marian A E; Langius, Jacqueline A E
- Abstract
Low skeletal muscle area (SMA) and muscle radiation attenuation (MRA) have been associated with poor prognosis in various patient populations. Both non-contrast and contrast CT scans are used to determine SMA and MRA. The effect of the use of a contrast agent on SMA and MRA is unknown. Therefore, we investigated agreement between these two scan options. SMA and MRA of 41 healthy individuals were analysed on a paired non-contrast and contrast single CT scan, and agreement between paired scan results was assessed with use of Bland-Altman plots, intraclass correlation coefficients (ICCs), standard error of measurements (SEM) and smallest detectable differences at a 95% confidence level (SDD 95 ). Analyses were stratified by tube voltage. Difference in SMA between non-contrast and contrast scans made with a different tube voltage was 7·0 ± 7·5 cm 2 ; for scans made with the same tube voltage this was 2·3 ± 1·7 cm 2 . Agreement was excellent for both methods: ICC: 0·952, SEM: 7·2 cm 2 , SDD 95 : 19·9 cm 2 and ICC: 0·997, SEM: 2·0 cm 2 , SDD 95 : 5·6 cm 2 , respectively. MRA of scans made with a different tube voltage differed 1·3 ± 11·3 HU, and agreement was poor (ICC: 0·207, SEM: 7·9 HU, SDD 95 : 21·8 HU). For scans made with the same tube voltage the difference was 6·7 ± 3·2 HU, and agreement was good (ICC: 0·682, SEM: 5·3 HU, SDD 95 : 14·6 HU). In conclusion, SMA and MRA can be slightly influenced by the use of contrast agent. To minimise measurement error, image acquisition parameters of the scans should be similar.
- Publication
Clinical physiology and functional imaging, 2018, Vol 38, Issue 3, p366
- ISSN
1475-097X
- Publication type
Journal Article
- DOI
10.1111/cpf.12422