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- Title
Involvement of inflammasome activation in lipopolysaccharide-induced mice depressive-like behaviors.
- Authors
Zhang, Yi; Liu, Lei; Peng, Yun-Li; Liu, Yun-Zi; Wu, Teng-Yun; Shen, Xiao-Liang; Zhou, Jiang-Rui; Sun, Ding-Ya; Huang, Ai-Jun; Wang, Xia; Wang, Yun-Xia; Jiang, Chun-Lei
- Abstract
The NLRP3 inflammasome is a cytoplasmic multiprotein complex of the innate immune system that regulates the cleavage of interleukin-1β and interleukin-18 precursors. It can detect a wide range of danger signals and trigger a series of immune-inflammatory reactions. There were plenty of studies indicating that activation of the immune system played pivotal roles in depression. However, the underlying mechanisms of immune-depression interactions remained elusive and there was no report about the involvement of inflammasome activation in depression.
- Publication
CNS neuroscience & therapeutics, 2014, Vol 20, Issue 2, p119
- ISSN
1755-5949
- Publication type
Journal Article
- DOI
10.1111/cns.12170