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- Title
Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation.
- Authors
Shi, Jian-Quan; Zhang, Chu-Chu; Sun, Xiu-Lan; Cheng, Xin-Xin; Wang, Jiang-Bo; Zhang, Ying-Dong; Xu, Jun; Zou, Hai-Qiang
- Abstract
The activation of nuclear factor-kappa B (NF-κB) and NLRP3 inflammasome is involved in neuroinflammation, which is closely linked to Alzheimer's disease (AD). In vivo and in vitro studies have suggested that artemisinin shows antiinflammatory effects in inflammation-related diseases. However, the impacts of artemisinin on AD have not been investigated.
- Publication
CNS neuroscience & therapeutics, 2013, Vol 19, Issue 4, p262
- ISSN
1755-5949
- Publication type
Journal Article
- DOI
10.1111/cns.12066