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- Title
Impact of metformin monotherapy versus metformin with oestrogen-progesterone on lipids in adolescent girls with polycystic ovarian syndrome.
- Authors
Bredella, Miriam A; McManus, Shilpa; Misra, Madhusmita
- Abstract
Hyperinsulinaemia is an important determinant of the polycystic ovarian syndrome (PCOS). In addition to lifestyle measures, therapeutic strategies include the use of oestrogen-progesterone combination pills (EP), and insulin sensitizers such as metformin, either alone or in combination. Data are limited regarding the impact of metformin alone vs metformin with EP on cardiometabolic risk in overweight adolescents with PCOS. We hypothesized that metformin alone would lead to an improvement in HbA1C and lipid levels in overweight adolescent girls with PCOS compared with meformin with EP.
- Publication
Clinical endocrinology, 2013, Vol 79, Issue 2, p199
- ISSN
1365-2265
- Publication type
Journal Article
- DOI
10.1111/cen.12028