We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Imbalance of different types of CD4<sup>+</sup>forkhead box protein 3 ( FoxP3)<sup>+</sup> T cells in patients with new-onset systemic lupus erythematosus.
- Authors
Ma, L.; Zhao, P.; Jiang, Z.; Shan, Y.; Jiang, Y.
- Abstract
The aim of this study was to examine the numbers of CD4+ CD25−forkhead box protein 3 ( FoxP3)+, CD4+ CD25+ FoxP3+ and CD4+ CXCR5+ FoxP3+ T cells in patients with new-onset systemic lupus erythematosus ( SLE). The numbers of CD4+ CD25− FoxP3+, CD4+ CD25+ FoxP3+ and CD4+ CXCR5+ FoxP3+ T cells and the concentrations of serum interleukin ( IL)-10 in 23 patients and 20 healthy controls ( HC) were measured. The potential correlations between CD4+ FoxP3+ T cells, serum IL-10 and clinical measures in SLE patients were analysed. In comparison with that in the HC, significantly reduced numbers of CD4+ CD25+ FoxP3+ and CD4+ CXCR5+ FoxP3+ T cells, but increased numbers of CD4+ CD25− FoxP3+ T cells, were detected, accompanied by significantly lower levels of serum IL-10 in the patients. Stratification analysis indicated the numbers of CD4+ CD25+ FoxP3+ and CD4+ CXCR5+ FoxP3+ T cells and serum IL-10 levels in the patients with seropositive anti-ds DNA were significantly less than that in those with seronegative anti-ds DNA. Treatment with the anti- SLE therapy, particularly with prednisone, leflunomide and methotrexate, significantly improved the imbalance of these types of FoxP3+ T cells and increased the concentrations of serum IL-10 in the drug-responding patients. The numbers of CD4+ CD25+ FoxP3+ T cells were correlated negatively with the values of SLE disease activity index ( SLEDAI), whereas the numbers of CD4+ CD25− FoxP3+ T cells were correlated positively with the values of SLEDAI, erythrocyte sedimentation rate ( ESR) and serum C3. In addition, the concentrations of serum IL-10 were correlated positively with the numbers of CD4+ CD25+ FoxP3+ T cells, but negatively with the values of SLEDAI, serum C3, CRP and ESR in these patients. Our data indicate that the imbalance of different types of FoxP3+ CD4+ T cells may contribute to the development of SLE in Chinese patients.
- Publication
Clinical & Experimental Immunology, 2013, Vol 174, Issue 3, p345
- ISSN
0009-9104
- Publication type
Academic Journal
- DOI
10.1111/cei.12189