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- Title
From an atypical wake-promoting agent to potent histamine-3 receptor inverse agonists.
- Authors
Dunn, Derek; Raddatz, Rita; Ator, Mark A; Bacon, Edward R; Chatterjee, Sankar
- Abstract
Utilizing atypical wake-promoting agent modafinil (inactive in both rH(3) and hH(3) binding assays) as a launching pad, a series of sulfinyl- and sulfone-derived H(3) receptor inverse agonists were developed. Brain-permeable compound 27, a potent member of the series displayed excellent selectivity against related family members (H(1), H(2), and H(4) receptors).
- Publication
Chemical biology & drug design, 2013, Vol 81, Issue 3, p433
- ISSN
1747-0285
- Publication type
Commentary
- DOI
10.1111/cbdd.12094