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- Title
Quercetin induces insulin secretion by direct activation of L-type calcium channels in pancreatic beta cells.
- Authors
Bardy, G; Virsolvy, A; Quignard, J F; Ravier, M A; Bertrand, G; Dalle, S; Cros, G; Magous, R; Richard, S; Oiry, C
- Abstract
Quercetin is a natural polyphenolic flavonoid that displays anti-diabetic properties in vivo. Its mechanism of action on insulin-secreting beta cells is poorly documented. In this work, we have analysed the effects of quercetin both on insulin secretion and on the intracellular calcium concentration ([Ca(2+)]i) in beta cells, in the absence of any co-stimulating factor.
- Publication
British journal of pharmacology, 2013, Vol 169, Issue 5, p1102
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/bph.12194