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- Title
Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice.
- Authors
Walentiny, Dm; Vann, Re; Mahadevan, A; Kottani, R; Gujjar, R; Wiley, Jl
- Abstract
Previous structure-activity relationship studies with analogues of the CB1 receptor antagonist rimonabant have demonstrated that a subset of these analogues with 3-substituent replacements of rimonabant's pyrazole core displayed cannabimimetic profiles seemingly independent of CB1 receptors. We sought to further evaluate these analogues in several behavioural models sensitive to detecting THC-like abuse liability.
- Publication
British journal of pharmacology, 2013, Vol 169, Issue 1, p10
- ISSN
1476-5381
- Publication type
Journal Article
- DOI
10.1111/bph.12099