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- Title
TCTP increases stability of hypoxia-inducible factor 1α by interaction with and degradation of the tumour suppressor VHL.
- Authors
Chen, Ke; Chen, Shuliang; Huang, Chunhua; Cheng, Hanhua; Zhou, Rongjia
- Abstract
The translationally controlled tumour protein (TCTP) plays an important role in maintaining cell proliferation and its high expression is associated with many tumours. The tumour suppressor von Hippel-Lindau protein (VHL) has been shown to function as an E3 ubiquitin ligase. Although great progress has been made, biological roles of these factors and relevant molecular mechanisms remain largely unknown.
- Publication
Biology of the cell, 2013, Vol 105, Issue 5, p208
- ISSN
1768-322X
- Publication type
Journal Article
- DOI
10.1111/boc.201200080