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- Title
ESCRT-II's involvement in HIV-1 genomic RNA trafficking and assembly.
- Authors
Ghoujal, Bashar; Milev, Miroslav P; Ajamian, Lara; Abel, Karen; Mouland, Andrew J
- Abstract
Several host proteins play crucial roles in the HIV-1 replication cycle. The endosomal sorting complex required for transport (ESCRT) exemplifies a large, multi-component host machinery that is required by HIV-1 for viral budding. ESCRT promotes the inward budding of vesicles from the membranes of late endosomes to generate multi-vesicular bodies. However, HIV-1 co-opts the ESCRT to enable outwards budding of virus particles from the plasma membrane, a phenomenon that is topologically similar to multi-vesicular body biogenesis. A role for ESCRTII in mRNA trafficking has been established in Drosophila in which the ESCRT-II components, Vps22 and Vps36, promote the localisation of the bicoid mRNA in the fertilised egg. This is achieved via specific interactions with the Staufen protein. In this work, we investigated a possible implication of ESCRT-II in the HIV-1 replication cycle.
- Publication
Biology of the cell, 2012, Vol 104, Issue 12, p706
- ISSN
1768-322X
- Publication type
Journal Article
- DOI
10.1111/boc.201200021