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- Title
Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice.
- Authors
Jung, S H; Sun, X; Ryu, W-S; Yang, B-S
- Abstract
Allergic contact dermatitis (ACD) is a delayed type of T cell-mediated cutaneous inflammatory response, in which multiple cell types are involved. Dasatinib and LCB 03-0110 are small molecule multityrosine kinase inhibitors, and they share remarkably similar target kinases such as the c-Src family, Btk and Syk, which play key roles in the cell signalling of T cells and other inflammatory cells.
- Publication
The British journal of dermatology, 2013, Vol 168, Issue 1, p112
- ISSN
1365-2133
- Publication type
Journal Article
- DOI
10.1111/bjd.12069