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- Title
Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension.
- Authors
Leeming, D J; Karsdal, M A; Byrjalsen, I; Bendtsen, F; Trebicka, J; Nielsen, M J; Christiansen, C; Møller, S; Krag, A
- Abstract
The hepatic venous pressure gradient (HVPG) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (PHT). During cirrhosis, remodelling of fibrotic tissue by matrix metalloproteinases (MMPs) is a permanent process generating small fragments of degraded extracellular matrix (ECM) proteins known as neoepitopes, which are then released into the circulation.
- Publication
Alimentary pharmacology & therapeutics, 2013, Vol 38, Issue 9, p1086
- ISSN
1365-2036
- Publication type
Journal Article
- DOI
10.1111/apt.12484