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- Title
Remission of refractory Crohn's disease by high-dose cyclophosphamide and autologous peripheral blood stem cell transplantation.
- Authors
Hasselblatt, P; Drognitz, K; Potthoff, K; Bertz, H; Kruis, W; Schmidt, C; Stallmach, A; Schmitt-Graeff, A; Finke, J; Kreisel, W
- Abstract
Despite advances in immunosuppressive therapy, up to 10% of patients with severe Crohn's disease (CD) remain refractory to conventional treatment. Limited evidence from pilot trials suggests that high-dose immunosuppression and autologous peripheral blood stem cell transplantation (autoPBSCT) may induce remission in these patients, but there is substantial controversy regarding the safety and efficacy of this approach.
- Publication
Alimentary pharmacology & therapeutics, 2012, Vol 36, Issue 8, p725
- ISSN
1365-2036
- Publication type
Journal Article
- DOI
10.1111/apt.12032