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- Title
Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries.
- Authors
Edvinsson, L; Ahnstedt, H; Larsen, R; Sheykhzade, M
- Abstract
Calcitonin gene-related peptide (CGRP) and its receptor are widely distributed within the circulation and the mechanism behind its vasodilation not only differs from one animal species to another but is also dependent on the type and size of vessel. The present study examines the nature of CGRP-induced vasodilation, characteristics of the CGRP receptor antagonist telcagepant and localization of the key components calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) of the CGRP receptor in human subcutaneous arteries.
- Publication
Acta physiologica (Oxford, England), 2014, Vol 210, Issue 4, p811
- ISSN
1748-1716
- Publication type
Journal Article
- DOI
10.1111/apha.12213